GNAT Family

Description

Vetting et al. 2005: The Gcn5-related N-acetyltransferases are an enormous superfamily of enzymes that are universally distributed in nature and that use acyl-CoAs to acylate their cognate substrates. In this review, we will examine those members of this superfamily that have been both structurally and mechanistically characterized. These include aminoglycoside N-acetyltransferases, serotonin N-acetyltransferase, glucosamine-6-phosphate N-acetyltransferase, the histone acetyltransferases, mycothiol synthase, protein N-myristoyltransferase, and the Fem family of amino acyl transferases.

Domain alignments

This family is also present in:

• Cyanidioschyzon merolae
• Galdieria sulphuraria
• Micromonas pusilla CCMP1545
• Micromonas sp. RCC299
• Ostreococcus lucimarinus
• Ostreococcus tauri
• Chlamydomonas reinhardtii
• Chlorella sp. NC64A
• Coccomyxa sp. C-169
• Physcomitrella patens
• Selaginella moellendorffii
• Oryza sativa subsp. indica
• Oryza sativa subsp. japonica
• Sorghum bicolor
• Zea mays
• Arabidopsis lyrata
• Arabidopsis thaliana
• Carica papaya
• Populus trichocarpa
• Vitis vinifera

References