version: 3.0
GNAT Family
Description
Vetting et al. 2005: The Gcn5-related N-acetyltransferases are an enormous superfamily of enzymes that are universally distributed in nature and that use acyl-CoAs to acylate their cognate substrates. In this review, we will examine those members of this superfamily that have been both structurally and mechanistically characterized. These include aminoglycoside N-acetyltransferases, serotonin N-acetyltransferase, glucosamine-6-phosphate N-acetyltransferase, the histone acetyltransferases, mycothiol synthase, protein N-myristoyltransferase, and the Fem family of amino acyl transferases.
Members of this familySHOULD possess Acetyltransf_1 domain
SHOULD NOT possess PHD domain
This family is also present in:
- Cyanidioschyzon merolae
- Galdieria sulphuraria
- Micromonas pusilla CCMP1545
- Micromonas sp. RCC299
- Ostreococcus lucimarinus
- Ostreococcus tauri
- Chlamydomonas reinhardtii
- Chlorella sp. NC64A
- Coccomyxa sp. C-169
- Physcomitrella patens
- Selaginella moellendorffii
- Oryza sativa subsp. indica
- Oryza sativa subsp. japonica
- Sorghum bicolor
- Zea mays
- Arabidopsis lyrata
- Arabidopsis thaliana
- Carica papaya
- Populus trichocarpa
- Vitis vinifera
General references
Vetting, MW; S de Carvalho, LP; Yu, M; Hegde, SS; Magnet, S; Roderick, SL; Blanchard, JS. 2005. Structure and functions of the GNAT superfamily of acetyltransferases. Arch. Biochem. Biophys. 433(1):212-26 PUBMEDID:15581578Design qRT-PCR primers using Quantprime